Informatics Publishing Limited

Atul R. Bendale ¹, Sachin B. Narkhede ², Anil G. Jadhav ², G. Vidyasagar ³

Affiliations
1 (Dept. of Pharmaceutical Chemistry) Smt. B. N. B. Swaminarayan Pharmacy College, NH-08, Salvav (Vapi), Gujarat, IN
2 Smt. B. N. B. Swaminarayan Pharmacy College, Salvav (Vapi), Gujarat, IN
3 Kutch University, Bhuj, Gujarat, IN

Abstract

The purpose of this study was to determine first-year bachelor of pharmacy student's computer backgrounds and attitudes. Fifty students from Smt. B. N. B. Swaminarayan Pharmacy College, Salvav, Vapi (Gujarat) completed a survey that assessed their computer experience, types of software used, and attitudes about computers. From this survey it is come to know that 24% students are daily user of computers, 30% students used computer once in a month, 16% twice in a month and 14% thrice in a month. one important aspect observe that all students (100%) are aware of computer applications in pharmaceutical field. Most (78%) had home computers; however, 20% said they relied on a school-based computer laboratory. Software use ranged from a high of 96% (MS WORD) to a low of 4% (Statistical Package). In case of MS-Office- 86% students have basic skill, 13% have intermediate skill and 1% has an expert skill. Most indicated positive attitudes about computers they feel apprehensive about learning to use a PC (88%). Students viewed computers as important parts of their professional education, but appeared to want courses that included both computer and human components. These findings suggest that faculty should consider differences in student's attitudes about and experiences with computers when planning computer-based course assignments and developing computer-based instructional innovations in Pharmacy field.

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Atul R. Bendale ¹, Jayk Khunt ¹, Sushil P. Narkhede ¹, Sachin B. Narkhede ¹, Anil G. Jadhav ¹, G. Vidyasagar ²

Affiliations
1 Smt. B. N. B. Swaminarayan Pharmacy College, Salvav (Vapi), Gujarat, IN
2 Dean (Pharmacy Department) Kutch University, Bhuj, Gujarat, IN

Abstract

Mechanochemistry is the emerging branch of chemical science which obeys the principles of green chemistry. The power of mechanical friction is the source of energy for completion of reaction. Basically it was classified in the metallurgical sciences but due to its compatibility and ease of practice it will readily adopted in science of chemical synthesis. Organics as well as inorganic substances can be subjected to modification by virtue of it. It appears to be a science with a sound theoretical foundation which exhibits a wide range of potential application. The simplest and best example is of KBr plates; it will induced by milling and pressing of analyte with KBr to form a disk for IR spectroscopy, resulting in a change of the spectrum of the analyte. So it was worthwhile to adopt this technique in synthesis of pharmaceuticals.

Keywords

Green Chemistry, Mechanochemistry, Mechanical Friction, Synthesis.

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Atul R. Bendale ¹, Neha Patel ¹, Sushil P. Narkhede ¹, Sachin B. Narkhede ¹, Anil G. Jadhav ¹, G. Vidyasagar ²

Affiliations
1 Smt. B. N. B. Swaminarayan Pharmacy College, Salvav (Vapi), Gujarat, IN
2 Dean (Pharmacy Department) Kutch University, Bhuj, Gujarat, IN

Abstract

A simple, highly efficient and green procedure for the condensation of aryl and alkyl 1, 2-diamines with α-diketones in the presence of different catalyst at room temperature is described. And the recycled catalyst was used for the next run under identical reaction conditions. Using this method, quinoxaline derivatives as biologically interesting compounds are produced in high to excellent yields and short reaction times. Present synthesis complies with principle of Green chemistry. As part of current studies, we here in report efficient practical technique of sonication reaction (sonosynthesis). The overall progress of the reaction was monitored by TLC and characterized by IR and NMR. Compared with traditional methods, these methods are more convenient and reactions can be carried out in higher yield, shorter reaction time and milder conditions, without generation of pollution and safer to analyst. The synthesized 2, 3-diphenyle quinoxaline was confirmed by physical constant and spectroscopic studies. Low cost, reuse of worn catalyst and maximum efficiency are some advantages of this synthesis. Compared with traditional method, this method is more convenient and reactions can be carried out in higher yield, shorter reaction time and milder conditions, without generation of pollution and safer to analyst. From these features present methods can be correlated for safer and efficient synthesis of other products.

Keywords

Sonochemistry, Quinoxaline, Catalyst.

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